1 Introduction

What if we could see the research landscape not as scattered trials, but as a living map of inquiry—constantly evolving, purposefully connected, and ethically aligned? With an AI-powered knowledge graph trained on the vast archive of HTA reports, could we finally chart clinical studies in real time, uncovering how each trial fits into the bigger picture—and whether it truly earns the burden it places on participants?

This book is in Open Review. I want your feedback to make the book better for you and other readers. To add your annotation, select some text and then click the on the pop-up menu. To see the annotations of others, click the in the upper right hand corner of the page